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KMID : 0366220170520040293
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Korean Journal of Hematology
2017 Volume.52 No. 4 p.293 ~ p.299
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STAT3 expression is associated with poor survival in non-elderly adult patients with newly diagnosed multiple myeloma
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Jung Sung-Hoon
Ahn Seo-Yeon
Choi Hyun-Woo
Shin Myung-Geun
Lee Seung-Shin
Yang Deok-Hwan
Ahn Jae-Sook
Kim Yeo-Kyeoung
Kim Hyeoung-Joon
Lee Je-Jung
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Abstract
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Background: Signal transducer and activator of transcription 3 (STAT3) is not only a key signaling mole-cule in the regulation of growth but is also involved in malignant transformation. We inves-tigated the prognostic significance of STAT3 expression in 94 non-elderly adult patients (aged 38 to 65 yr) with newly diagnosed multiple myeloma (MM).
Methods: Tumor cell-specific phosphotyrosine-STAT3 (PY-STAT3) expression at the time of diag-nosis was evaluated with dual immunohistochemical (IHC) staining for PY-STAT3 and CD138.
Results: PY-STAT3 positivity was detected in 10 patients (10.6%), including three who showed strong expression. PY-STAT3-positive patients had higher serum C-reactive protein and calcium levels at diagnosis than did PY-STAT3-negative patients. PY-STAT3 positivity had predictive value for poor progression-free survival (PFS; P=0.001) and overall survival (OS; P=0.003). Among the 60 patients who received frontline autologous stem cell trans-plantation, PY-STAT3-positive patients had poorer PFS than did PY-STAT3-negative pa-tients (4.2 vs. 19.2 mo, respectively; P=0.013). Multivariate analysis identified PY-STAT3 expression as an independent prognostic factor for PFS (relative risk [RR]=2.706, P=0.014) and OS (RR=3.091, P=0.044).
Conclusion: These data show that PY-STAT3 positivity, as determined using dual IHC, is a marker of poor prognosis in non-elderly adult patients with MM.
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KEYWORD
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STAT3, Multiple myeloma, Prognosis
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